Careers at Vaxcyte

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: We are seeking a skilled and passionate Azure Cloud Engineer to join our growing engineering team. In this role, you will design, build, and maintain secure, scalable cloud infrastructure on Microsoft Azure, using Infrastructure as Code (IaC) best practices — primarily Terraform. You will collaborate with cross-functional teams to deliver reliable hosting solutions that meet the highest standards of security and compliance. The ideal candidate holds an Azure certification, brings strong software engineering fundamentals, and has hands-on experience with a broad range of Azure services. Experience in validated or regulated environments, particularly within the Life Sciences sector, is considered a valuable plus. Essential Functions: Infrastructure & Cloud Engineering Design, deploy, and manage Azure cloud infrastructure using Terraform and Infrastructure as Code (IaC) best practices. Provision and maintain Azure services including AKS, ADF, Microsoft Fabric, Managed SQL Instances, Virtual Machines, and Batch Accounts. Build and maintain secure virtual networks, including firewalls, private endpoints, NSGs, and network segmentation. Ensure infrastructure meets organizational security standards, including identity and access management via Azure AD / Entra ID and RBAC. Configure and monitor logs and notifications to proactively identify issues and minimize downtime. Monitor Azure end of support components and plan changes and updates to the infrastructure as needed. Develop, test and maintain backup and disaster recovery plans for infrastructure. Security & Compliance Enforce security controls and conduct regular audits to maintain compliance with organizational and regulatory requirements. Support validated and regulated environmental requirements (e.g. GxP, ISO, SOC 2) where applicable. Monitor infrastructure health and respond to security incidents promptly and effectively. Collaboration & Continuous Improvement Collaborate with software, data engineering, and platform teams to support application hosting and CI/CD pipelines. Document architecture decisions, runbooks, and operational procedures to support team knowledge sharing. Evaluate and adopt new Azure services and cloud-native tooling to improve platform reliability and efficiency. Contribute to monitoring, logging, and observability improvements across the infrastructure estate. Requirements: Bachelor’s degree in computer science, Engineering, or related field (or equivalent experience) with a minimum of 5+ years of experience. Other combinations of education and/or experience may be considered. Microsoft Azure certification (e.g. AZ-104, AZ-305, or equivalent) is required. Proven experience with Terraform for provisioning and managing cloud infrastructure at scale.Strong understanding of Azure networking: VNets, subnets, NSGs, private DNS, and firewall configurations. Hands-on experience with Azure services: AKS, ADF, Managed SQL, VMs, and Batch Accounts. Solid software engineering fundamentals: version control (Git), scripting (PowerShell/Bash/Python), and code review practices. Experience implementing cloud security controls, including identity management and RBAC. Excellent communication skills with the ability to explain technical concepts to varied audiences. Strong architectural and systems design capability with an infrastructure-as-code mindset. Ownership mindset with accountability for reliability, security, and performance outcomes. Commitment to automation, documentation, and operational excellence. Ability to balance technical rigor with delivery timelines in a fast-paced environment. Collaborative team player who works effectively across engineering and business functions. Preferred Qualifications Experience working in validated or regulated environments (e.g. GxP, ISO, SOC 2). Background in the Life Sciences, Pharmaceutical, or Healthcare sectors. Familiarity with Microsoft Fabric and modern data platform architectures. Knowledge of DevOps and GitOps workflows, including Azure DevOps or GitHub Actions. Experience with cloud cost optimization strategies and governance frameworks. Reports to: Associate Director, Data Systems, CMC IT Location: San Carlos, CA Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Hybrid (3 days per week onsite) Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $163,000 - $191,000 (SF Bay Area). Salary ranges for non-California locations may vary. Equal Opportunity We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Recruitment Fraud Notice Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers .

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: The Senior Manager, Quality Assurance will serve as the Quality Assurance lead for Drug Substance intermediates and custom raw material activities, ensuring all operations performed at Contract Manufacturing Organizations (CMOs) meet Vaxcyte’s quality standards and global regulatory requirements. This role acts as the primary QA representative across internal and external cross-functional teams, providing oversight of deviations, investigations, risk assessments, change controls, and CAPAs. The Senior Manager will conduct detailed reviews of batch records, disposition packages, and technology transfer documents, driving timely issue resolution with CMOs and escalating risks as needed. In addition, this position will develop and enhance QA procedures, support continuous improvement initiatives, and contribute subject-matter expertise on biologics manufacturing and Quality Systems. The ideal candidate brings deep GMP knowledge, strong communication and collaboration skills, and the ability to thrive in a fast-paced, matrixed environment while managing multiple priorities. Essential Functions: QA Manufacturing representative for Drug Substance intermediates and custom raw material at Vaxcyte. Represent QA at internal and external cross functional team meetings. Review and approve internal and external documentation for compliance such as deviations, risk assessments, change controls, and CAPAs. Responsible for thorough QA review of CMO executed batch records in compliance with current regulatory guidance and industry practices and follow up on CMO responses. Review disposition package of Drug Substance intermediates and custom raw materials per global applicable regulatory requirements and provide to management for release. Develop, implement and maintain procedures and policies as they apply to Drug Substance intermediates and custom raw material manufacturing for the Vaxcyte quality organization as needed. Drive resolution of quality performance issues with contract manufacturers and proactively escalate issues to Vaxcyte management. Provide guidance on supplier manufacturing investigations. Support technology transfer activities and review of technology transfer documents. Participate in process improvement projects. Interact with key stakeholders to develop solutions to complex issues while promoting quality standards of excellence. Requirements: BS or BA with a minimum of 8 years of Quality Assurance experience. Other combinations of education and/or experience may be considered. In-depth knowledge of GMPs, FDA/EMA regulations and ICH guidelines. Strong attention to detail. Knowledge in both clinical and commercial product desired. Excellent verbal, written, and interpersonal communication skills. Experience leading and contributing through influence and working in cross functional teams. Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects. Ability to adapt to changing priorities. Strong overall knowledge of biologics manufacturing processes and Quality Systems. Required experience with good documentation practices, technical writing, and cGMP standards. Ability to travel 10-15% domestic and international. Reports to: Director, Quality Assurance Location: Visp, Switzerland Work Arrangement: Hybrid (minimum of 3 days per week) Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. Equal Opportunity We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Recruitment Fraud Notice Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers .

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: The Executive Director, Quality Assurance, External Manufacturing is responsible for leading the External Manufacturing Quality function and executing the quality strategy across Vaxcyte’s global network of Contract Development and Manufacturing Organizations (CDMOs) and external partners. In a highly outsourced operating model, this role ensures that externally executed GMP activities are compliant with global regulatory requirements and Vaxcyte quality standards, supporting product quality, supply continuity, and regulatory readiness. This leader drives a proactive, risk-based quality approach and implements scalable systems, governance, and partnerships to enable operational excellence across the external network, supporting clinical development, BLA readiness, and commercial supply. The Executive Director owns external quality performance and operational decision-making within the function, while escalating critical risks and aligning with VP-level strategy. This role requires strong cross-functional leadership and the ability to influence internal and external stakeholders in a highly matrixed environment. Essential Functions: Own quality performance across the external network, ensuring compliance, supply continuity, and effective management of quality risk, with escalation of critical risks to VP-level as appropriate. Provide end-to-end QA leadership for externally executed GxP activities, including manufacturing and release of drug substance, drug product, components, and critical raw materials. Serve as the senior QA leader for external operations, representing Quality in cross-functional and executive forums, and influencing decisions across Technical Operations, CMC, Regulatory, and Supply Chain. Establish and maintain strategic partnerships with external partners, driving accountability, performance management, and continuous improvement. Lead quality governance across the external network, including KPIs, escalation pathways, and risk-based oversight models focused on critical processes and high-risk partners. Oversee and drive resolution of complex, cross-organizational quality issues, ensuring robust investigations, root cause analysis, and sustainable CAPAs. Provide oversight and decision authority for batch disposition and product release, ensuring timely, compliant supply of clinical and commercial materials. Drive inspection readiness across the external network, including PAI and global health authority inspections, and serve as a key QA representative during inspections. Provide strategic QA leadership for technology transfer, process validation, and lifecycle management across external sites. Build, lead, and develop a high-performing External Quality organization, including talent development, succession planning, and organizational scalability. Champion a strong quality culture across internal teams and external partners, reinforcing accountability, transparency, and continuous improvement. Requirements: BS/BA required, with a minimum of 16 years of progressive experience in Quality Assurance within biopharmaceuticals, including significant leadership in external manufacturing and CDMO oversight, vaccines experience desirable. Other combinations of education and/or experience may be considered. Deep expertise in GMP regulations, FDA and global regulatory expectations, and ICH guidelines Extensive experience operating within a highly outsourced/CDMO-based manufacturing model Proven track record of leading complex external quality networks, driving performance and outcomes without direct authority Strong experience supporting technology transfer, process validation, and lifecycle management across multiple external sites Demonstrated success in inspection readiness and regulatory inspections, including pre-approval inspections (PAIs) Experience establishing governance frameworks, and performance metrics for external partners Strong background in risk management and quality systems, with the ability to apply risk-based decision-making in a GxP environment Proven ability to influence at the executive level, driving alignment across cross-functional teams and external partners Demonstrated experience building, leading, and scaling high-performing teams in a complex, fast-paced environment Strong business acumen, with the ability to balance quality, compliance, and supply continuity to support clinical and commercial objectives Key Competencies Strategic Leadership in Outsourced Models External Partner Governance & Influence Risk-Based Quality Oversight Regulatory Inspection Readiness (PAI Focus) Executive Communication & Cross-Functional Leadership Complex Problem Solving & Decision-Making Organizational Development & Talent Leadership Reports to: Vice President, Quality Assurance Location: San Carlos, CA Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Hybrid (minimum of 3 days per week onsite) Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $300,000 - $350,000 (SF Bay Area). Salary ranges for non-California locations may vary. Relocation: This role is not eligible for relocation assistance. #LI-JN1 Equal Opportunity We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Recruitment Fraud Notice Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers .

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: We are seeking a dedicated and experienced Senior Manager, Clinical Quality Assurance, to join our dynamic team. The ideal candidate will have a strong background in quality management within a clinical setting and a passion for maintaining the highest standards of clinical excellence. This role requires an individual who can work with teams to ensure compliance with regulatory requirements and achieve our mission of delivering high-quality healthcare solutions. Essential Functions: Lead global investigations and support teams with CAPA preparation in compliance with applicable regulations/guidelines, customer requirements, Standard Operating Procedures (SOPs) and project specific guidelines/instructions. Manage Quality Issues and serious breach investigations. Review, approve Investigations, Root Cause Analysis (RCA), Corrective and Preventive Action (CAPA) and Effectiveness Check (EC) plans. Track until closure quality events from Quality Issues, Audits, Inspections or during similar QA activities. Manage/oversee quality event update in eQMS. Plan, schedule, and conduct risk based and For Cause audits of clinical investigators sites, CROs, and other GCP vendors. Support regulatory agency inspection readiness activities, including mock inspections, gap assessments, and inspection response coordination. Evaluate policies and procedures for compliance with applicable regulations/guidelines and provide recommendations to management for continuous process improvements. Support in QA initiatives/projects for quality, process improvements. Promotes a quality mindset and quality excellence approach to all activities. Understands and interprets regulatory agencies policies and guidance as it pertains to GCP requirements and assists in the implementation of compliant processes at Vaxcyte. Requirements: BA or BS in related field. Minimum of 9 years of experience in Quality Assurance within the clinical or pharmaceutical industry. Other combinations of education and/or experience may be considered. Knowledge of QMS system (Veeva preferred). GCP QA Certification preferred (RQAP-GCP, or similar). Experience across all phases of clinical development. Knowledge of applicable FDA regulations and ICH guidelines. Proficiency in QA tools and software (Veeva preferred). Excellent communication and interpersonal skills, with the ability to work collaboratively with diverse teams. Strong analytical and problem-solving skills, with a keen attention to detail. Ability to travel up to 15%. Reports to: Senior Director, Clinical Quality Assurance Location: San Carlos, CA; Open to Remote Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Hybrid (minimum of 3 days per week onsite) / Remote Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $163,000 – $191,000 (SF Bay Area). Salary ranges for non-California locations may vary. Equal Opportunity We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Recruitment Fraud Notice Please be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers .